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causes dermatology hematology palpable druginduced medications petechiae petechial rash arterial bruising compared comparison embolism erythemas hemorrhage hus kidneyinjury microangiopathies microangiopathy
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Rashes- THE ALGORITHMIC ... , an algorithmic ... Nonpalpable purpura ... #Algorithm #Nonpalpable ... #Differential
Causes of Purpura - Differential Diagnosis Disruption in Vascular Integrity: • Trauma, Infection, Vasculitis, Drug induced
- Differential ... , Drug induced vasculitis ... Primary hemostasis: Thrombocytopenia ... #nonpalpable #palpable ... #Diagnosis #vasculitis
Drug-Induced Thrombocytopenia The diagnosis of drug-induced thrombocytopenia can be made only by demonstrating resolution of thrombocytopenia once
Drug-Induced Thrombocytopenia ... drug-induced thrombocytopenia ... patients with drug-induced ... purpura. ... #Differential #
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 Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... → Palpable • Thrombocytopenia ... necrosis), Trauma, Drugs ... #nonpalpable #palpable ... #Diagnosis #vasculitis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... induced - Bone ... #Differential # ... rheumatology #palpable #nonpalpable
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table • Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis Table ... • Thrombotic Thrombocytopenic ... Purpura (TTP) ... Complement-mediated TMA - Drug-induced ... #diagnosis #HUS
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Diagnosis Algorithm ... e.g. prolonged/induced ... of uterus • Drugs ... purpura (ITP) ... #Diagnosis #Algorithm
Drug Induced Kidney Injury • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy • Osmotic
Drug Induced Kidney ... induced vasculitis ... #KidneyInjury #differential ... #diagnosis #algorithm ... #nephrology #Medications
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Platelet count reduced ... leukaemia) - Drug-induced ... infections - Vasculitis ... peds #pediatrics #diagnosis ... #differential #
Causes of Seizures - Differential Diagnosis Algorithm Unprovoked - Epilepsy: • Focal: Simple, Complex • Generalized: Absence,
Diagnosis Algorithm ... malformation, Aneurysm, Vasculitis ... Toxic: Alcohol, Medication ... , Recreational drugs ... #Diagnosis #Algorithm
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