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Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
nodules, Deep ulcers ... Urticarial/LCV) - Cryoglobulinemic ... - GPA Cutaneous ... : • Behcet Disease ... #dermatology #rheumatology
Skin Ulcers of the Lower Legs / Feet - Differential Diagnosis Algorithm
Physical:
• Pressure
• Trauma
• Radiation
Vascular:
• Arterial
insufficiency • Vasculitis ... cell carcinoma • Melanoma ... ulcerative #skinrash ... #dermatology #Differential ... Diagnosis #Algorithm #causes
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
insufficiency • Vasculitis ... carcinoma • Melanoma ... Mycosis fungoides (cutaneous ... #ulcerative #skinrash ... #dermatology #Differential
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... Connective tissue disease ... (5%): PAN > GPA ... #dermatology #semiology ... lesions #diagnosis #clinical
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Bullae/Blisters • Ulceration ... reticularis Differential ... #dermatology #rash
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... genital aphthous ulcers ... , cutaneous, ocular ... • ANCA (Dx: GPA ... #rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Purpura - Skin ulcers ... Syndrome: • Clinical ... • Autoimmune diseases ... - GPA, EGPA, microscopic ... Henoch-Schönlein purpura) • Cutaneous
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... arthralgia, arm/leg ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic ... purpura (lower legs
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
more): Genital ulceration ... ) • Cutaneous Lesions ... ) Differential Diagnosis ... Lymphoma Ocular melanoma ... Syndrome #diagnosis #management
Monkeypox

What?
Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus
Viral zoonotic disease that is
Viral zoonotic disease ... three weeks Clinical ... epiglottitis, or ulcerative ... soles • Oral ulcers ... #Dermatology