9 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... arthralgia, and arthritis ... systemic lupus erythematosus ... (SLE), rheumatoid ... arthritis, Sjögren's
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... likely it will be clinically ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren ... Syndrome, Myositis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
Pathogenesis and Clinical ... diseases like rheumatoid ... arthritis (RA) ... systemic lupus erythematosus ... (SLE) Signs / Symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
ischemia - Skin: erythematous ... • Cogan Syndrome ... Diagnosis: Systemic rheumatic ... systemic lupus erythematosus ... Presentation - Systemic Symptoms
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... ANCA-associated vasculitis ... , rheumatoid arthritis ... Clinical Features ... Induced Lupus: • Symptoms
Differential Diagnosis of Acute Arthritis

Crystal-induced arthritis: Calcium oxalate, gout, cholesterol, pseudogout, hydroxyapatite crystals

Infectious arthritis: Bacteria, fungi,
: Behçet syndrome ... ,* rheumatoid arthritis ... systemic lupus erythematosus ... ), systemic vasculitis ... hyperlipoproteinemia,* meniscal
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... meningitis), MCC CNS symptoms ... (Clinical Dx). ... #diagnosis #management ... #signs #symptoms
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... Demyelinating syndromes ... #signs #symptoms
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis: • Systemic rheumatic ... Presentation: Systemic Symptoms ... ischemia • Skin: Erythematous ... • Progressive symptoms ... • Cogan syndrome