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differential management rheumatology pathophysiology signs lupus arteritis ascorbicacid classification effusions erythematosus gca giantcell joint knee manifestations monoarthritis monoarticular mucocutaneous musculoskeletal
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Arthralgia, Arthritis ... Myopathy (Also caused ... #MSK #Musculoskeletal ... #Complications ... #diagnosis
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
Causes of Knee Effusions ... - Differential Diagnosis ... - SLE - Behcet ... Ligamentous injuries - Meniscal ... #msk #physicalexam
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... Differential Diagnosis ... Presentation - Systemic Symptoms ... , and SLE) • Urinalysis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... diseases, such as SLE ... Presentation: Systemic Symptoms ... • Progressive symptoms ... tract, and often causes
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis ... #signs #symptoms ... #complications
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... constitutional symptoms ... weeks) Can Be Caused ... • SLE • Psoriatic ... #MSK #rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... and ophthalmic complications ... = vasculitis vs ... absence of visual symptoms ... Temporal #Signs #Symptoms
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Deficiency) - Diagnosis ... • Persons with psychiatric ... Psychiatric symptoms ... nonimmune hemolysis MSK ... , or any other cause
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Bilateral signs and/or symptoms ... Evaluate for NMO, SLE ... • Infectious causes ... Disorders: - SLE ... - Sjogren - Vasculitis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... phenomenon (16%) MSK ... Arthralgia and Arthritis
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