18 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... #Pathophysiology ... #nephrology #diagnosis
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Wasting vs SIADH - Pathophysiology ... Neurological event 2) Sodium ... SaltWasting #SIADH #Pathophysiology ... #diagnosis #nephrology ... #hyponatremia #comparison
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
of Hyperkalemia ... • SPS - Sodium ... #Hyperkalemia # ... pharmacology #table #comparison ... #nephrology
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
associated with hypokalemia ... overdose) - Sodium ... renal Fanconi syndrome ... #differential #diagnosis ... #nephrology #Causes
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Inherited (AR) hypokalemic ... thiazide-sensitive sodium ... thiazide-sensitive sodium ... #diagnosis #nephrology ... #management #pathophysiology
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
ON (UNa < 30): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... Hyponatremia #Algorithm #diagnosis ... #sodium #nephrology
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
BRASH Syndrome ... S - Shock H - Hyperkalemia ... DrEricStrong #BRASH #Syndrome ... #diagnosis #management ... #pathophysiology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
Present (Uosm ≥100): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... #differential #diagnosis ... #table #sodium ... #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Differential Diagnosis ... Framework and Management ... #Differential #Diagnosis ... #Management #causes ... #treatment #nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... : • Pathophysiology ... hydration - Hyperkalemia ... #TLS #diagnosis ... #management #hematology