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diagnosis hematology algorithm anemia classification management nonpalpable purpura rash thrombocytosis workup blood bruising clinical extravascular hemolysis intravascular oncology palpable petechiae
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... microangiopathy: Thrombotic thrombocytopenic ... Extravascular #Causes ... #differential # ... diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... : - Thrombocytopenia ... DIC/TTP/HUS - Hemolytic ... SLE) - Viral infections ... #nonpalpable #dermatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... HUS • DIC • Vasculitis ... • Infection ... #Hematology
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... Internal - Infectious ... #Diagnosis #Causes ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential ... circulation - Infections ... Extravascular #Differential ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Schistocytes, thrombocytopenia ... cardiac valve, vasculitis ... inclusions - If infection ... #Anemia #Differential
Causes of Purpura - Differential Diagnosis Disruption in Vascular Integrity: • Trauma, Infection, Vasculitis, Drug induced
Causes of Purpura ... - Differential ... : • Trauma, Infection ... Primary hemostasis: Thrombocytopenia ... #Differential #
Vascular Skin Lesions - Differential Diagnosis Algorithm - Petechiae < 0.2 cm diameter - Purpura 0.2
Skin Lesions - Differential ... #Vascular #Vasculitis ... #SkinRash #dermatology ... #Differential # ... Diagnosis #Algorithm #causes
Skin Ulcers of the Lower Legs / Feet - Differential Diagnosis Algorithm Physical: • Pressure • Trauma • Radiation Vascular: • Arterial
Legs / Feet - Differential ... insufficiency • Vasculitis ... Ulcers #ulcerative #skinrash ... #dermatology #Differential ... Diagnosis #Algorithm #causes
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
with devastating differential ... purpura occurs in vasculitic ... inflammation or infection ... as autoimmune vasculitis ... #Diagnosis #Dermatology
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