38 results
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Immune-Mediated Necrotizing Myopathy ... Antisynthetase Syndrome ... #Comparison #Managment ... #algorithm #Rheumatology ... #Differential
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
load Drug-induced myopathy ... 5-15% of lupus myopathy ... #differential # ... diagnosis #comparison ... #rheumatology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
Ring-Enhancing Lesions ... Ring-Enhancing Lesions ... Diagnosis- Compatible syndrome ... + MRI lesions + ... #Brain #differential
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
, TIF1y, NXP2, Mi ... Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... clinical #diagnosis #rheumatology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... proximal weakness Myopathy ... mediated necrotizing myopathy ... EMG) studies • MRI ... #Weakness #Differential
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver Lesions ... Resonance Imaging (MRI ... #Contrast #CT #MRI ... POCUS #radiology #differential ... #diagnosis #comparison
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... Brown-Séquard Syndrome ... Posterior Cord Syndrome ... - Radiation myelopathy ... #lesions #differential
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome ... tests in Behcet syndrome ... Behcet disease) Differential ... adenopathy (PFAPA) syndrome ... signs #symptoms #rheumatology
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
PSS: Sjogren syndrome ... CTILD #Diagnosis #Differential ... #Comparison #Table ... #Pulmonary #Rheumatology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS) - Differential ... late-onset nemaline myopathy ... capillary leak syndrome ... • Schnitzler syndrome ... #Diagnosis #hematology