28 results
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... symptoms can mimic ... Diagnosis via genetic ... #management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Etoposide/VP16 (100 mg ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
fever syndromes Clinical ... Fever is the main clinical ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Non-Hodgkin's Lymphoma - Comparison ... Autoimmune diseases • Clinical ... Differential Diagnosis ... #oncology #diagnosis ... #differential #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
kg/day vs. 2.5 mg ... : >3 symptoms, or ... Dexamethasone 10 mg ... q12h -> 10 mg q6h ... #management #hematology
Anterior ischemic optic neuropathy (AION) - Recognition of giant cell arteritis (GCA)

1) Is visual loss caused
Clinical manifestations ... • Cephalic symptoms ... Doppler US : halo sign ... GiantCellArteritis #GCA #Rheumatology ... Ophthalmology #Diagnosis
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
life Causes and clinical ... and duration of symptoms ... angioedema Other symptoms ... #rheumatology # ... comparison #table
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogenemia Symptoms ... : • + Clinical ... levels < than 50 mg ... #rheumatology # ... hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
minimal tumor burden Diagnosis ... immunophenotype Clinical ... Leukemia #oncology #hematology ... #hemeonc #diagnosis ... #management
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
patients with clinically ... stimulation Clinical ... prednisone (1000 mg ... to 1250 mg) without ... #management #neurology