11 results
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives
1,3-Beta-D-Glucan
 • Cell wall component of many fungi
Galactomannan Testing ... Sensitivity Specificity ... and False Positives ... 96% • Higher specificity ... Galactomannan #Fungal #Testing
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
Sensitivity & Specificity ... 96% - Higher specificity ... breakthrough IFI in HM • False ... recipients, CGD pts • False ... Frozen ice-pops (in setting
1,3 Beta-D-Glucan and Galactomannan - Pathogens, and Testing Characteristics
1,3 ß-D-glucan:
 • Most fungi excluding mucor and
Pathogens, and Testing ... and pneumocystis False ... other fungi • False ... Galactomannan #Pathogens #Testing ... #Sensitivity #Specificity
Invasive Aspergillus (IA) - Diagnosis and Management
Aspergillus is ubiquitous in nature. Most invasive infections are caused
Invasive Aspergillus ... and Management Aspergillus ... Diagnosis and Testing ... : • Aspergillus ... sensitivity and low specificity
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
-> Serological Testing ... Fungal (Histoplasma/Aspergillus ... -> Serological Testing ... -> Serological Testing ... Diagnosis #Management #Algorithm
Diagnostic algorithm for the workup of hypercalcemia. The diagnostic workup for patients presenting with hypercalcemia rests
Diagnostic algorithm ... ) was 0.80 and specificity ... Thus, further testing ... #Differential #Algorithm
Diagnosis Adrenal Insufficiency - Algorithm

Step 1) Screening Test: 6-8AM Cortisol Level
 - Early morning cortisol levels
Insufficiency - Algorithm ... have almost 100% specificity ... require Cosyntropin testing ... Insufficiency #Algorithm
D-dimer
Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
can cause a ↓ specificity ... (i.e. more false ... Specificity can ... yrs of age) the specificity ... adjusted d-dimer testing
USMLE Epidemiology and Biostatistics Summary
Meta-Analysis: pools data from several studies (greater power), limited by quality/bias of
Specificity (rule ... FN) Higher specificity ... probability of getting ... null when it’s false ... when it is indeed false
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
sensitivity and specificity ... Urinary antigen testing ... ASPERGILLOSIS • Aspergillus