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diagnosis management signs encephalopathy erythematosus hematology sle systemic treatment activation b1 barre cerebritis cns cryoglobulinemia cryoglobulins deficiency gbs guillain leukostasis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Other brainstem syndromes ... (e.g. oculomotor ... Hypothalamic or thalamic syndromes ... AQP4-lgG disease; e.g ... erythematosus, Sjögren syndrome
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... hyperviscosity syndrome ... rasburicase Tumor Lysis Syndrome ... unless worrisome EKG ... #Tumor #Lysis #Syndrome
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management Diagnosis - Caine Criteria (2 of
Diagnosis - Caine Criteria ... dysfunctions ( e.g ... Cerebellar dysfunction (e.g ... treatment can improve symptoms ... development of Korsakoff syndrome
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... Endocrine disorders (e.g ... lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... underlying disease (eg ... • Infection (eg ... hypersensitivity syndromes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... cryoglobulinemia syndrome ... 20% Sjögren's syndrome ... tissue disorder (e.g
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
post-sarcoidosis fatigue syndrome ... of diagnosis (e.g ... Specific sarcoidosis syndromes ... ) • Löfgren syndrome ... • Heerfordt syndrome
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
• Or brainstem syndromes ... Radiographic findings (eg ... McDonald diagnostic criteria ... Laboratory findings (eg ... VEP’s: EEG of visual
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Encephalopathy Syndrome ... Clinico-Radiological Syndrome ... syndrome by 24 ... Paraneoplastic syndrome ... • EEG: With persistent
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