37 results
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Loop Diuretics (e.g ... 4) Thiazides (e.g ... HCTZ) 5) Potassium-sparing ... ) #Pathophysiology ... #Nephrology #Nephron
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Loop diuretic (e.g ... Metolazone) 5) Potassium-sparing ... diuretics (e.g. ... nephron #diuretics #pharmacology ... #nephrology #medications
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... ) Loop agents (eg ... Adenosine #Nephron #Pathophysiology ... Sites #Action #nephrology ... #pharmacology
Initial treatment of renal bone disease and cinacalcet for secondary hyperparathyroidism
Phosphate binders reduce hyperphosphataemia and hyperparathyroidism.
Initial treatment ... phosphate binders also ... the first-line treatments ... #Pharmacology #Pathophysiology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC ... differential #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Management of Pediatric Kidney Stones
Acute Managment:
 • Pain relief: NSAIDs, opioids
 • Facilitating passage of stone:
therapy (MET): e.g ... Recurrence: • For ALL ... - Calcium as ... involvement: eyes, TFT, ECG ... Management #Pediatrics #nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... organ damage • Treatment ... Lysis Syndrome: • Pathophysiology ... Low calcium • Treatment ... unless worrisome EKG
Anaphylaxis: Treatments (Acute)
Additional Info:
 • IV steroids may be considered for prevention of late phase reactions.
Anaphylaxis: Treatments ... well as allergy ... resuscitation may also ... Treatment: • ... #Management #pathophysiology
Algorithm for the Treatment of Uremic Pruritus
Nonpharmacologic Treatments:
 • Daily topical emollient
 • Avoidance of extremes
Algorithm for the Treatment ... Evidence-Based Off-Label Pharmacologic ... Treatments of Uremic ... nalfurafine 2.5 mcg ... #management #nephrology
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... cyclosilicate #Potassium ... #Hyperkalemia #treatment ... #pharmacology # ... table #comparison #nephrology