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Jaundice Differential Diagnosis: A short guide

By Dr. Khudhur Mohammed @khudhur_moh

#jaundice #gastroenterology #algorithm #differential #diagnosis #hyperbilirubinemia #bilirubin
Jaundice Differential Diagnosis ... #jaundice #gastroenterology ... #differential #diagnosis ... hyperbilirubinemia #bilirubin
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
- Differential Diagnosis ... Hyperbilirubinemia #direct #bilirubin ... #Differential #Diagnosis ... #Algorithm #gastroenterology ... #hepatology
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Unconjugated bilirubin ... Testing #workup #diagnosis ... #hematology #hemolysis
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
Stratification Model ... Followup #algorithm #diagnosis ... #management #hematology
Irritable Bowel Syndrome (IBS) in Pregnancy
 - Pathophysiology
 - Pharmacotherapy
 - Nonpharmacological Treatment

Emory Gastroenterology and Hepatology
Treatment Emory Gastroenterology ... and Hepatology ... IBS #Pregnancy #diagnosis ... #gastroenterology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... Increased Serum bilirubin ... Causes #Workup #Hematology ... #Diagnosis *
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
birth with serum bilirubin ... associated with bilirubin ... in conjugated bilirubin ... #hepatology #diagnosis ... #gastroenterology
Endoscopic Ultrasound (EUS) - 6 Landmarks

#Endoscopic #Ultrasound #EUS #Landmarks #diagnosis #gastroenterology
Endoscopic Ultrasound ... #Endoscopic #Ultrasound ... EUS #Landmarks #diagnosis ... #gastroenterology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Phosphatase and Bilirubin ... initial insult Bilirubin ... ASTALT #AlkPhos #Bilirubin ... #Hepatology #Pathophysiology ... #Diagnosis #LFTs
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential Diagnosis ... / unconjugated bilirubin ... #Differential #Diagnosis ... #Algorithm #hematology