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differential hematology anemia palpable purpura agglutinin atlas basics cold cvid ddxof disease endocrinology gout hyperuricemia hypogammaglobulinemia immunodeficiency immunology intravascular key
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... Extravascular Causes ... usually IgM) (e.g. primary ... #Hemolytic #Intravascular ... #diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Reticulocytosis • Primary ... Hypersplenism • Secondary ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... #Algorithm #Causes
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Algorithm. ... vasculitis) or disorders ... of primary or secondary ... may be affected (commonly ... #Dermatology #Rash
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... Post-splenectomy Primary ... #Causes #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Diagnosis: • hemolytic ... • Compensated hemolysis ... hemolysis on rewarming ... agglutinin #disease #hemolytic
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
- Differential Diagnosis ... Algorithm Primary ... Lymphoproliferative Disorders ... Leukemia (CML) - Hemolytic ... #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... leakage of RBC's secondary ... /Quantity: • Primary ... : ITP • Secondary ... DIC/TTP/HUS - Hemolytic
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Common Variable ... Immunodeficiency disorder ... infection risk secondary ... and autoimmune hemolytic ... DDX - Other causes
Primary Dermatological Lesions Primary lesions are physical changes in the skin considered to be caused directly by
associated with secondary ... They are most commonly ... a generalized disorder ... nettle sting #Diagnosis ... #Dermatology #Skin
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