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differential hepatology causes abnormal aptt gradient interpretation management prolonged pt saag serum analysis bacterial bleeding bruising chemistry comparison deficiencies deficiency
Deciphering the SAAG - Serum to Ascites Albumin Gradient Ascites is either made in the liver sinusoid
made in the liver ... sinusoid (hepatic ... or not by the liver ... Matherly @liverprof #Diagnosis ... #Hepatology #SAAG
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
or venipuncture sites ... • Severe Liver ... 100mg/dL) - Heparin ... #diagnosis #causes ... treatment #management #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Medications - Heparin ... ) • Advanced Liver ... Post-partum • Acute DIC ... table #comparison #diagnosis ... #hematology #deficiency
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
Serum Ascites Albumin ... - Differential Diagnosis ... - Massive liver ... failure - Hepatic ... #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... of portal HTN: ascites ... portal HTN: • Ascites ... INR, bilirubin, albumin ... #causes #hepatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... deficiency • Liver ... Cholesterol emboli • Septic ... #Differential #Diagnosis ... #hematology #rheumatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Laboratory Findings in Hepatic ... Hypoalbuminemia - Decreased albumin ... As a result of DIC ... #Hepatology #Laboratory ... #Diagnosis #Testing
Spontaneous Bacterial Peritonitis (SBP) - Diagnosis and Management Ascites PMN > 250/mm3 ? Nosocomial or hospital acquired. Recent
Peritonitis (SBP) - Diagnosis ... and Management Ascites ... Presentation in septic ... response Give IV albumin ... dysfunction or liver
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... (DIC) c. ... Prolonged #Causes #diagnosis ... #differential #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Production: • Albumin ... • Coagulation ... replaced by non-hepatic ... disease: > 2 • NASH ... #chemistry #diagnosis
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