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differential causes abnormal aptt hepatology interpretation prolonged pt albumin bleeding bruising chemistry comparison deficiencies deficiency dermatology disseminated emergencies fluid gradient
Deciphering the SAAG - Serum to Ascites Albumin Gradient Ascites is either made in the liver sinusoid
either made in the liver ... or not by the liver ... Matherly @liverprof #Diagnosis ... #Hepatology #SAAG ... #Differential #Analysis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
or venipuncture sites ... • Severe Liver ... 100mg/dL) - Heparin ... #diagnosis #causes ... treatment #management #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Medications - Heparin ... ) • Advanced Liver ... Post-partum • Acute DIC ... table #comparison #diagnosis ... #hematology #deficiency
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... deficiency • Liver ... Cholesterol emboli • Septic ... #Differential #Diagnosis ... #hematology #rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... (DIC) c. ... Prolonged #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... intravascularcoagulation (DIC ... #differential #hematology ... #coagulation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Albumin • Coagulation ... replaced by non-hepatic ... disease: > 2 • NASH ... #chemistry #diagnosis ... #differential #Hepatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... inhibitor of a coagulation ... Acquired: • Heparin ... disease • Acute DIC ... #Hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... G6PD first) DIC ... intravascular coagulation ... - CRS: fever, rash ... Oncology #HemeOnc #Diagnosis
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