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treatment disease lupus stills adultonset aosd blood comparison druginduced product reactions syndrome table activation chronic cll coagulation deficiencies deficiency dermatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Management Summary ... versus DIL • ... • Immunologic Workup ... #Management #Summary ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... SCLE-DIL (terbinafine ... • Immunologic Workup ... comparison #table #rheumatology ... #diagnosis #management
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
) • Advanced Liver ... RA, SLE), Post-partum ... • Acute DIC - ... table #comparison #diagnosis ... #hematology #deficiency
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... arthritis, Skin rash ... MAS, Visceral, DIC ... #management #treatment ... #rheumatology
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
Summary Kawasaki ... rarely occurs in adults ... Conjunctivitis, Mucositis, Rash ... Polymorphous rash ... KD #vasculitis #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... IL-6, TNF-a, ? ... maculopapular rash ... Disease #AOSD #rheumatology ... #diagnosis #management
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... /splenomegaly, liver ... anti-lL6R, anti-ILI #Adult ... #rheumatology # ... management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Fibrinogen level, ↑ sIL ... Autoimmune diseases: SLE ... +++, Adult-onset ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... erythematosus [SLE ... thrombocytopenia • Liver ... #Management #Hematology ... #Rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... non-Hodgkin lymphoma SLL ... phenomenon CLL Diagnosis ... #workup #oncology ... #hematology
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