19 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Dermatomyositis ... can present with rash ... triad of ILD, myositis ... #Autoimmune #Myositis
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... Anti-Jo, +Anti-Mi2 Dermatomyositis ... muscle weakness, rash ... Inclusion Body Myositis ... , +Anti-dsDNA, Myositis
Causes of Rhabdomyolysis - Differential Diagnosis
 • Drugs & Toxins (Statins, alcohol, cocaine)
 • Direct Muscle
Causes of Rhabdomyolysis ... Damage (Trauma/crush ... Muscle Disease (myositis ... Differential #Diagnosis #Causes
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Tetanus, Transverse Myelitis ... , Polymyositis/dermatomyositis ... Neuromuscular #Weakness #Causes
Dermatomyositis
A middle-aged man describes progressive difficulty combing his hair and rising from a seated position over
Dermatomyositis ... This is a case of ... dermatomyositis ... 1) heliotrope rash ... AndreMansoor #Dermatomyositis
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Subacute to Chronic Causes ... Inflammatory myopathy: dermatomyositis ... Inclusion body myositis
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
ANTI-MDA5 DERMATOMYOSITIS ... (blue-purple) rash ... • Erythematous rash ... Women • ~20% of cases ... Men • ~50% of cases
Leg Pain - Differential Diagnosis Framework

Bone/Joint Causes of Leg Pain:
 • Fracture
 • Arthritis
 • Gout/pseudogout
Bone/Joint Causes ... Hematoma Venous Causes ... Compartment syndrome • Myositis ... • Trauma • Crush ... blunt trauma, crush
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Immobilization, Crush ... (polymyositis/Dermatomyositis ... Management #Summary #causes
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Management Summary Causes ... Immobilization - Crush ... : Polymyositis/Dermatomyositis ... Diagnosis #Management #causes