14 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Necrotizing myopathy ... Dermatomyositis ... and anti-HMGCR myopathy ... @AnnKumfer #Autoimmune
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... Anti-Jo, +Anti-Mi2 Dermatomyositis ... muscle weakness, rash ... Inclusion Body Myositis ... , +Anti-dsDNA, Myositis
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Subacute to Chronic Causes ... : dermatomyositis ... - Autoimmune ... Inclusion body myositis
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Tetanus, Transverse Myelitis ... Mitochondrial myopathy ... , Polymyositis/dermatomyositis ... Neuromuscular #Weakness #Causes
Dermatomyositis
A middle-aged man describes progressive difficulty combing his hair and rising from a seated position over
Dermatomyositis ... This is a case of ... dermatomyositis ... 1) heliotrope rash ... usually indicates myopathy
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
proximal weakness Myopathy ... mediated necrotizing myopathy ... • Autoimmune: ... Inclusion body myositis ... Muscle Biopsy: Dermatomyositis
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Myopathies (IIM's) RASH ... • Overlap Myositis ... features of another autoimmune ... Inclusion body myositis ... #Rash
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Symptoms: • Gottron rash ... INCLUSION BODY MYOSITIS ... statins - probably caused ... #Myositis #Myopathy
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Immobilization, Crush ... Hyperthyroidism), Autoimme ... (polymyositis/Dermatomyositis ... Management #Summary #causes
Dermatomyositis with heliotrope rash, shawl sign, and Gottron's papules

A middle-aged man describes progressive difficulty combing his
Dermatomyositis ... with heliotrope rash ... out this is a case ... of dermatomyositis ... usually indicates myopathy