9 results
Dermatomyositis
A middle-aged man describes progressive difficulty combing his hair and rising from a seated position over
This is a case of ... 1) heliotrope rash ... shawl sign, and 3) Gottron's ... usually indicates myopathy ... HeliotropeRash #Gottrons
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Necrotizing myopathy ... Dermatomyositis ... holster sign, and Gottron's ... and anti-HMGCR myopathy
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... Anti-Jo, +Anti-Mi2 Dermatomyositis ... muscle weakness, rash ... Inclusion Body Myositis ... , +Anti-dsDNA, Myositis
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Critical Illness Myopathy ... Subacute to Chronic Causes ... : dermatomyositis ... Inclusion body myositis
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Tetanus, Transverse Myelitis ... Mitochondrial myopathy ... , Polymyositis/dermatomyositis ... Neuromuscular #Weakness #Causes
Dermatomyositis with heliotrope rash, shawl sign, and Gottron's papules

A middle-aged man describes progressive difficulty combing his
Dermatomyositis ... shawl sign, and Gottron's ... out this is a case ... shawl sign, and 3) Gottron's ... usually indicates myopathy
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
ANTI-MDA5 DERMATOMYOSITIS ... (blue-purple) rash ... • Erythematous rash ... interphalangeal joints: Gottron ... papules • Inverse Gottron
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Symptoms: • Gottron ... rash (Gottron papules ... and Gottron sign ... statins - probably caused
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
Anti-NXP-2 Dermatomyositis ... (blue-purple) rash ... • Erythematous rash ... interphalangeal joints: Gottron ... Muscle atrophy may cause