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diagnosis differential rheumatology management inflammatory neurology rhabdomyolysis treatment autoimmune ck clinical comparison dermatology idiopathic muscle photo weakness algorithm cocaineinduced corticosteroidinduced
Myositis and Myopathies #ESR #CK #Differential diagnosis of myopathy #Inflammatory #myopathies #Dermatomyositis #muscle weakness #Polymyositis #Inclusion body myositis #Polymyalgia rheumatica #Fibromyalgia #Hypothyroid myopathy #Muscle stiffness #Drug-induced
Myositis and Myopathies ... #Inflammatory #myopathies ... #Dermatomyositis ... Inclusion body myositis ... #Drug-induced myopathies
Idiopathic Inflammatory Myopathies - Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... - Dermatomyositis ... Inclusion Body Myositis ... #Inflammatory #Myopathies ... #Idiopathic #Myopathy
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... Anti-Jo, +Anti-Mi2 Dermatomyositis ... muscle weakness, rash ... Inclusion Body Myositis ... #Myopathies #myopathy
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Necrotizing myopathy ... Dermatomyositis ... can present with rash ... and anti-HMGCR myopathy
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Subacute to Chronic Causes ... - Metabolic Myopathies ... : dermatomyositis ... Inclusion body myositis
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
(IIM's) RASH ... • Overlap Myositis ... Any inflammatory myopathy ... Inclusion body myositis ... #Rash
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
proximal weakness Myopathy ... mediated necrotizing myopathy ... • Metabolic myopathies ... Muscle Biopsy: Dermatomyositis ... certain drug-induced myopathies
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
• Myalgia • Myositis ... • Inflammatory myopathy ... polymyositis, dermatomyositis ... inclusion body myositis ... → Inflammatory myopathies
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Tetanus, Transverse Myelitis ... Mitochondrial myopathy ... , Polymyositis/dermatomyositis ... Neuromuscular #Weakness #Causes
Dermatomyositis A middle-aged man describes progressive difficulty combing his hair and rising from a seated position over
Dermatomyositis ... This is a case of ... dermatomyositis ... 1) heliotrope rash ... usually indicates myopathy
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