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diagnosis rheumatology druginduced hemeonc oncology treatment activation anemia aplastic comparison differential dil emergencies hemophagocytic hhv8 hlh inflammatory kaposi kics kshv
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
pro-inflammatory cytokines ... disease • Systemic lupus ... SJIA], systemic lupus ... #Diagnosis #Management ... #Hematology #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms ... constitutional symptoms ... 40, F:M 9:1 • Clinical ... #diagnosis #management
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... → cytokines to ... renal failure Clinical ... are not caused ... skin (16-32%): lupus
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... and petechiae Causes ... • Improve the symptoms ... Anemia #oncology #hematology ... #diagnosis #management
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... Summary Causes ... Immobilization - Crush ... Dermatomyositis Clinical ... : • Triad of symptoms
KSHV Inflammatory Cytokine Syndrome (KICS) Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV Inflammatory Cytokine ... Syndrome (KICS) ... Working Case Definition ... Symptoms: Fatigue ... #diagnosis #management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
): - Hematologic ... Treat underlying cause ... “big & sticky” cells ... steroids, dialysis Cytokine-release ... - CRS: fever, rash
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... Constitutional symptoms ... NPSLE rare, Malar rash ... #DIL #rheumatology ... diagnosis #treatment #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... Clinical Presentation ... Common Signs and Symptoms ... • Cytokine storm ... #Hematology #HemeOnc
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