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diagnosis rheumatology druginduced classification comparison complications differential dil geography infection manifestations microbiology mucocutaneous table treatment vasculitides vasculitis
Anaplasma Infection - Anaplasma phagocytophilum Pathophysiology: • Obligate, intracellular bacteria • Transmitted via blacklegged tick —
Anaplasma Infection ... Pathophysiology ... within morulae Signs ... and symptoms: ... shaking chills • Rash
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... plugging -> Discoid Rash ... Malar (butterfly) Rash ... #diagnosis #signs
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... NPSLE rare, Malar rash ... constitutional symptoms ... Manifestations: Malar rash ... Usual therapeutic management
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Constitutional symptoms ... NPSLE rare, Malar rash ... is rare in DIL, SCLE-DIL ... Discontinuation of causal ... diagnosis #treatment #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... Presentation - Systemic Symptoms ... purpura: strong sign ... vasculitis, and SLE
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