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Alteplase (t-PA) for Acute Ischemic Stroke: 
Dosage, Mixing, and Administration Instructions

#TPA #Thrombolytics #Stroke #CVA #Dosage #Dosing
Acute Ischemic Stroke ... Instructions #TPA ... Thrombolytics #Stroke ... #CVA #Dosage #Dosing ... #Instructions #Pharmacology
Indications for tPA in Stroke:
 • Clinical diagnosis of ischemic stroke
 • Measurable neurologic deficit
 •
Indications for tPA ... to intravenous tPA ... present, in which case ... #Indications #tPA ... #Stroke #cva #management
tPA Code Stroke Dosing Chart

Total Dose = 0.9 mg/kg (maximum dose =90 mg)
 - give 10%
tPA Code Stroke ... over 1 hour #TPA ... #Dosing #Dose #CVA ... Thrombolytics #Stroke ... #Pharmacology
Mydriasis and Miosis - Differential Diagnosis Framework

Causes of Mydriasis:
Dilated pupils (mydriasis) more than 7mm
 • Unilateral
Diagnosis Framework Causes ... MDMA (Ecstacy), TCA ... Hypothermia Causes ... Nicotine, Heat Stroke ... ophthalmology #causes
Drug-Induced Seizures - OTIS-CAMPBELL

O - Organophosphate, oral hypoglycemics, opioid
T - TCA, theophylline
I - Isoniazid, Insulin
S -
hypoglycemics, opioid T - TCA ... Seizures #Medication #Causes ... #Differential #Pharmacology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... leading to slow Ca ... - CLASS 1C: Strong ... Antiarrhythmics #Pharmacology ... Classification #Classes
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
- CLASS 1C: Strong ... receptors, and Ca ... MOA: Block slow Ca ... Vaughan #Williams #Pharmacology ... Classification #Classes
Causes of Syncope

NEUROLOGICAL
 - CVA/Stroke
 - Cancer
 - Carotid Stenosis
 - Parkinson’s Disease
 - Psychosis
 -
Causes of Syncope ... NEUROLOGICAL - CVA ... /Stroke - Cancer ... - Seizure - TIA ... /Mini Stroke -
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
> PR3 60% • GPA ... tract, and often causes ... Palpable purpura: strong ... • ANA (Suggest CTD ... • ANCA (Dx: GPA