91 results
Granular & “Muddy Brown” Casts on Urine Microscopy
A. Finely granular cast B. slightly coarser granular cast
“Muddy Brown” Casts ... Finely granular cast ... coarser granular cast ... (mb) granular cast ... #Granular #MuddyBrown
Examples of varying granular and granular/waxy mixed casts: 
A: coarse granular/broad-waxy (and surrounding white blood cells);
granular/waxy mixed casts ... #Granular #MuddyBrown ... #Casts #Urine #
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... but in severe cases ... Nephritic #Nephrotic #Syndromes
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy - Casts ... Acellular Casts ... • Hyaline Casts ... "Muddy Brown" Casts ... suggestive of nephrotic sydnrome
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... hematuria (RBC casts ... Nephritic #Nephrotic #Syndrome
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
Between Nephrotic Syndrome ... and Nephritic Syndrome ... == Nephrotic Syndrome ... Red blood cell casts ... Red blood cell casts
Muddy Brown Sclera: Brownish discoloration of sclera occasionally seen in African Americans. 
It is a variant
Ophthalmology #Normal #MuddyBrown ... #Sclera #AA #Photo
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... heme-granular casts ... Fatty - Nephrotic syndrome ... 34t5DgJ #Urinary #Casts
There are two patterns of T-wave abnormality in Wellens’ syndrome:
-Type A = Biphasic, with initial positivity
abnormality in Wellens’ syndrome ... negativity (25% of cases ... inverted (75% of cases ... #EKG #Wellens #Syndrome
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Secondary amyloid A (AA ... : • Nephrotic syndrome ... Carpal tunnel syndrome ... light chain AA ... IL-1 & IL-6 → AA