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diagnosis management immunology bloodcultures bloodstream c5c9deficiency catheter crbsi differential glomerulonephritis gonorrhea humoral immunity infection infective meningitis negative pathogenesis primarycare progressive
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... pathogens Bacterial ... activation -> Complement ... #pathophysiology
Gonorrhea: Pathophysiology - Neonatal Transmission -> Direct contact of patient mucosa with mother's infected mucosa while
Gonorrhea: Pathophysiology ... eradication of pathogen ... Pathogen cleared ... activation of complement ... #Gonorrhea #Pathophysiology
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
with Infective Endocarditis ... have a fastidious bacteria ... this be a non-bacterial ... pathogen? ... Diagnosis #Management #Algorithm
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
produced from pathogens ... (bacteria, viruses ... Opsonization: Abs coat pathogens ... Neutralization: Abs bind to pathogen ... Humoral #Immunity #pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Cryoglobulinemia, Endocarditis ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Pathogenesis of meningitis Risk factors for pathogen entry include immunocompromised state (HIV positive, cancer, chemotherapy patients,
Risk factors for pathogen ... patients, etc.), bacteremia ... , viremia, endocarditis ... Following pathogen ... #Meningitis #Pathophysiology
Suspected catheter-related bloodstream infection - Management Algorithm • Temperature 37.8 C • Rigors
infection - Management Algorithm ... Persistent fever and/or bacteremia ... metastatic infection (endocarditis ... • Resistant pathogens ... infection #Management #Algorithm
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
DEFINITION AND PATHOPHYSIOLOGY ... • Pathophysiology ... NETs), cytokines, complement ... • Pathogens: ... Gram-positive/-negative bacteria
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