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diagnosis management causes differential immunology abscess bacteremia bloodstream c5c9deficiency catheter crbsi gonorrhea hematology humoral immunecompromised immunity immunocompromised infection infectiousdiseases lung
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... pathogens Bacterial ... tissue -> Fatigue, fever ... #pathophysiology
Gonorrhea: Pathophysiology - Neonatal Transmission -> Direct contact of patient mucosa with mother's infected mucosa while
Gonorrhea: Pathophysiology ... eradication of pathogen ... Pathogen cleared ... activation of complement ... #Gonorrhea #Pathophysiology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
produced from pathogens ... (bacteria, viruses ... Opsonization: Abs coat pathogens ... Neutralization: Abs bind to pathogen ... Humoral #Immunity #pathophysiology
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
Rigors And Bacteremia ... response to a pathogen ... hypothalamus → fever ... PATHOPHYSIOLOGY: ... #Pathophysiology
Suspected catheter-related bloodstream infection - Management Algorithm • Temperature 37.8 C • Rigors
infection - Management Algorithm ... • Persistent fever ... and/or bacteremia ... and/or bacteremia ... • Resistant pathogens
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... HypospIenism • Bacteremia ... • Encapsulated Bacteria ... Periodontal Disease Complement ... Infection #Fever
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess Pathophysiology ... : • 80% have fever ... Intervention: - Fevers ... Lung Abscess Pathogens ... : • Aerobic Bacteria
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
• Pathophysiology ... NETs), cytokines, complement ... • Pathogens: ... Gram-positive/-negative bacteria ... • Symptoms: Fever
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