136 results
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
of Peripheral Weakness ... No Objective Weakness ... Oculomotor • Myasthenia ... Lambert-Eaton Myasthenic ... #Peripheral #Weakness
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Myasthenia Gravis ... Overview Myasthenia ... variable degree of weakness ... Limb- proximal weakness ... Severe bulbar weakness
Diagnosis of Myasthenia Gravis - Physical Exam Maneuvers
 • Sustained lateral gaze for seconds to elicit
Diagnosis of Myasthenia ... due to laryngeal weakness ... for neck flexor weakness ... BrighamMedRes #Myasthenia ... #Gravis #PhysicalExam
Drugs associated with worsening of Myasthenia Gravis (MG):
•	D-penicillamine 
•	Botulinum toxin.
•	Telithromycin
•	Fluoroquinolones 
•	Quinine
•	Magnesium
•	Macrolide antibiotics 
•	Corticosteroids (may cause transient
with worsening of Myasthenia ... prevent prolonged myasthenic ... higher risk of myasthenic ... because of bulbar weakness
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... or respiratory weakness ... mild to moderate weakness ... or generalized weakness ... and in myasthenic
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Myalgia, Muscle weakness ... Psychosis, Deafness ... of movement, Deafness ... Symptoms #Diagnosis #PhysicalExam ... #Endocrinology
Myasthenia Gravis
Signs, Symptoms and Testing - Likelihood Ratios
Does this patient have myasthenia gravis?
JAMA. 2005 Apr 20;293(15):1906-14.
Myasthenia Gravis ... this patient have myasthenia ... #Diagnosis #Myasthenia ... LikelihoodRatios #PhysicalExam
Curtain Sign - Enhanced Ptosis in Myasthenia Gravis
Because of bilateral eyelid innervation, when the more affected
Enhanced Ptosis in Myasthenia ... Enhanced #Ptosis #Myasthenia ... clinical #video #physicalexam
Ocular Myasthenia Gravis on Physical Exam

A 41yo female was referred by her neurologist for double vision.
Ocular Myasthenia ... non-localized EOM weakness ... Myasthenia gravis ... eyelid #Ocular #Myasthenia ... #Gravis #PhysicalExam
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Generalized Weakness ... NMJ disorder (Myasthenia ... #Generalized #Weakness