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Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis ... variable degree of weakness ... Limb- proximal weakness ... Severe bulbar weakness ... Gravis #diagnosis #management
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... or respiratory weakness ... mild to moderate weakness ... or generalized weakness ... Gravis #diagnosis #management
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... Lambert-Eaton myasthenic ... myopathy #diagnosis #management
Myasthenia Gravis - Ptosis, Diplopia, Blurred Vision Acute Myasthenic Crisis • Triggered by infection, medication • Respiratory
Myasthenia Gravis ... Vision Acute Myasthenic ... ventilation #Myasthenia
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
of Peripheral Weakness ... No Objective Weakness ... Oculomotor • Myasthenia ... Lambert-Eaton Myasthenic ... #Peripheral #Weakness
Drugs associated with worsening of Myasthenia Gravis (MG): • D-penicillamine • Botulinum toxin. • Telithromycin • Fluoroquinolones • Quinine • Magnesium • Macrolide antibiotics • Corticosteroids (may cause transient
with worsening of Myasthenia ... prevent prolonged myasthenic ... higher risk of myasthenic ... because of bulbar weakness
Diagnosis of Myasthenia Gravis - Physical Exam Maneuvers • Sustained lateral gaze for seconds to elicit
Diagnosis of Myasthenia ... due to laryngeal weakness ... for neck flexor weakness ... fatigable limb weakness ... BrighamMedRes #Myasthenia
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Generalized Weakness ... NMJ disorder (Myasthenia ... #Generalized #Weakness
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Eaton Syndrome, Myasthenia ... Neuromuscular #Weakness
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy • Central or peripheral neurologic disease
Proximal Muscle Weakness ... neurologic disease • Myasthenia
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