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Drugs associated with worsening of Myasthenia Gravis (MG): • D-penicillamine • Botulinum toxin. • Telithromycin • Fluoroquinolones • Quinine • Magnesium • Macrolide antibiotics • Corticosteroids (may cause transient
with worsening of Myasthenia ... prevent prolonged myasthenic ... Patients with MuSK-MG ... higher risk of myasthenic ... because of bulbar weakness
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis ... variable degree of weakness ... Limb- proximal weakness ... immunologic assay - MuSK ... Severe bulbar weakness
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
of Peripheral Weakness ... No Objective Weakness ... Oculomotor • Myasthenia ... Lambert-Eaton Myasthenic ... #Peripheral #Weakness
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
anti—muscle-specific kinase (MuSK ... antibodies - MuSK-positive ... or respiratory weakness ... mild to moderate weakness ... or generalized weakness
Ocular Myasthenia Gravis on Physical Exam A 41yo female was referred by her neurologist for double vision.
Ocular Myasthenia ... non-localized EOM weakness ... Myasthenia gravis ... tumor, and always ask ... PhysicalExam #clinical #video
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 Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Demyelinating Disease (MS ... Eaton Syndrome, Myasthenia ... Neuromuscular #Weakness
Diagnosis of Myasthenia Gravis - Physical Exam Maneuvers • Sustained lateral gaze for seconds to elicit
Diagnosis of Myasthenia ... due to laryngeal weakness ... for neck flexor weakness ... fatigable limb weakness ... BrighamMedRes #Myasthenia
Curtain Sign - Enhanced Ptosis in Myasthenia Gravis Because of bilateral eyelid innervation, when the more affected
Enhanced Ptosis in Myasthenia ... Enhanced #Ptosis #Myasthenia ... Gravis #clinical #video
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 Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Generalized Weakness ... NMJ disorder (Myasthenia ... #Generalized #Weakness
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy • Central or peripheral neurologic disease
Proximal Muscle Weakness ... neurologic disease • Myasthenia
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