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Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... Liver Injury: ... • Infectious: HAV
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... • Infectious: ... #Injury #Differential ... #Diagnosis #Causes
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... cardiorenal syndrome) • Liver ... #Kidney #Injury ... Classification #diagnosis ... #nephrology
Miliary Pattern - Chest Radiology
 • Miliary opacities are scattered, small (1 -4 mm) nodules
 •
diffuse inhalational injury ... Differential Diagnosis ... Opacities: • Infectious ... - Mycobacterium ... Tuberculosis, NTB
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Coagulation Failure Infections ... Injury (DILI) ... gastroenterology #management ... #diagnosis
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Acute Kidney Injury ... (AKI) - Differential ... Diagnosis Framework ... Immune-mediated, Infection-mediated ... Diagnosis #nephrology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Kidney Injury AKI ... - Differential ... Diagnosis HEMODYNAMIC ... Post-infectious ... #Diagnosis #nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... (AKI) - Differential ... Diagnosis Framework ... AIN: Medication, Infection ... Diagnosis #nephrology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
injury < 26 weeks ... ALT: ↑ • GGT/5-NT ... nucleotidase (5-NT ... #chemistry #diagnosis ... #differential #
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... > 20x normal - Acute ... 10-20x normal - Infection ... transaminitis #differential ... #diagnosis