17 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... Diseases: • Systemic lupus ... #Diagnosis #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... • Blood smear: Differential ... Warm #Antibody #Autoimmune ... diagnosis #management #treatment ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
- Hemolytic anemia ... (aPL) 30-45% Differential ... autoantibodies #signs #symptoms ... #mimickers #differential ... #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Splenomegaly 5) Symptoms ... of anemia or thrombocytopenia ... Constitutional symptoms ... marrow failure with anemia ... Leukemia #oncology #hematology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... context of other symptoms ... Thyroid, Autoimmune ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... rheumatologic diseases ... lymphopenia, low PLT • Anemia ... : • Symptoms limited ... Erythematosus #Diagnosis #Rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... of anemia include ... CLL (older) • Autoimmune ... younger pts) Differential ... #hematology #diagnosis
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
belonging to the Mycobacterium ... Hematologic malignancy ... Bone Marrow - Anemia ... • Clinical (Symptoms ... #Infections #differential
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... constitutional symptoms ... Rheumatologic Disease ... Lyme disease) • Mycobacterium ... Diagnosis #MSK #rheumatology