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Map of proliferative blood disorders. 

By Ariella Coler-Reilly @ariellastudies

#Algorithm #classification #proliferative #blood #disorders #leukemia #hematology #oncology
#Algorithm #classification ... #disorders #leukemia ... #hematology #oncology ... #diagnosis #CML ... #CLL #AML #Map
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
: ALL, CML, AML, ... • (Peripheral eosinophilia ... Neutrophils • Immature/Myeloblasts ... Age: 50-60 • Auer ... #Hematology #Oncology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... , Sudan Black, Auer ... • Lymphoid (CLL ... CD23, o CML ... #Disorders #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
iron deficiency, hemolysis ... Chronic inflammatory disorders ... Chronic myeloid leukemia ... (CML) - Dr. ... Diagnosis #Causes #hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
Basophilia - Differential ... the total white blood ... Myeloproliferative Disorders ... (CML) - associated ... Diagnosis #causes #hematology
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
cells within the myeloblast ... (neutrophils, eosinophils ... disorders: > 100,000 ... Neutrophil bands ... part automated differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoid malignancy (CLL ... malignancies -> CLL ... younger pts) Differential ... significance (MGUS), CLL ... #anemia #hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
of peripheral blood ... on the left Myeloblast ... Tissue damage • Leukemia ... cultures, including blood ... neutrophil #WBC #CBC #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... (CML) • Felty ... Leukemia • Idiopathic ... count with differential ... Syndromes #diagnosis #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... nodosum • Immune hemolytic ... Workup: • Full Blood ... Immunohistochemical studies (to differentiate ... #hematology #oncology