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hematology causes management algorithm nephrology workup classification anemia chronic hemolytic leukemia rheumatology syndrome syndromes bee cancer gastroenterology kidney laboratory lactate
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... Neutrophils • Immature/Myeloblasts ... - infiltrates (anemia ... Leukemia #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... cells can indicate disease ... lymphoproliferative disorders ... microglobulin Treatment ... #workup #oncology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... anemia (sometimes ... Unstable hemoglobin disorders ... RBC #Morphology #differential ... #diagnosis #hematology
Causes of Dizziness / Lightheadedness - Differential Diagnosis Algorithm Lightheaded, unsteady, disoriented - Non-vertigo Organic Disease • Presyncope/Vasodepressor
Diagnosis Algorithm ... Hyperventilation • Anemia ... Anxiety • Panic Disorder ... Lightheadedness #Neurology ... #Differential #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... infection, autoimmune disorder ... lymphoid malignancy (CLL ... younger pts) Differential ... IgM Includes Disorders
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... leukemia in adults • Disorder ... minimal tumor burden Diagnosis ... chemotherapy for low-risk disease ... Lymphocytic #Leukemia #oncology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... • Rheumatic disorders ... • Celiac disease ... effect following treatment ... Iron deficiency anemia
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Chronic hemolytic anemia ... pulmonary Langerhans cell ... , thyroid disorders ... Classification #Diagnosis ... #Differential #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... Diagnosis and Workup ... (CVID, WAS), (neurologic ... not required in all ... #Differential #
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