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differential anca antibody antineutrophil arthritis classification disease diseases laboratory mds myelodysplasia myelodysplastic pediatrics peds purpura rheumatic rheumatoid sle syndromes testing
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... erythematosus ... #antibodies #diagnosis ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lupus erythematosus ... leukemia • Lung ... #Lupus #Erythematosus ... #Diagnosis #Rheumatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
- SLE (systemic ... lupus erythematosus ... infiltration (e.g. leukaemia ... infections - Vasculitis ... pediatrics #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... lupus erythematosus ... LFT • ESR • ANA ... ) pattern: antibodies ... #rheumatology #
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Neutrophils • Immature/Myeloblasts ... PLT: Petechiae, bruising ... • Tumor lysis syndrome ... #Hematology #Oncology ... #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Easy or unusual bruising ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... lupus erythematosus ... (SLE) - Antinuclear ... antibodies, which ... #Rheumatology
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