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differential sle symptoms systemic dermatology extravascular intravascular mimickers monoclonal nonpalpable oncology paraproteinemias
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... anemia): ... purpura (TTP), ... usually IgG) (e.g. lupus ... #hematology #anemia
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... CAUSES OF PALPABLE ... PURPURA: Vasculitis ... #hematology #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
, Purpura, Urticaria ... ) Blood (75%): Anemia ... #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... #Diagnosis #autoantibodies ... #differential #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
sign of cutaneous ... ischemia • Skin: Erythematous ... tract, and often causes ... ) • Palpable purpura ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
et diutinum Neurologic ... ) Autoantibodies ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology
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