28 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Clinically ... Relevant HES Variants ... Treatment Algorithm ... #HES #Hematology ... #eosinophilia #
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia Syndrome ... clinical manifestations ... #HES #eosinophilia ... #diagnosis #hematology ... #differential #
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... entities, but has ... this distinction has ... implications : TTP has ... Diagnosis #Table #Hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
significant: > 10% Band ... Band neutrophils ... Cell population has ... appreciate the value of band ... neutrophil #WBC #CBC #hematology
Scleroderma Like Conditions - Differential Diagnosis
Eosinophilic Fasciitis:
 - Orange peel induration (peau d'orange) of proximal extremities
Like Conditions - Differential ... with sparing of hands ... the mainstay of treatment ... #Scleroderma #Differential ... comparison #table #dermatology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
eruption that may ... Resolution > 15 days Differentials ... disease: symptomatic treatment ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(HUS) • Other ... usually IgG) (e.g. lupus ... disease, Copper and ... Extravascular #Causes #differential ... #diagnosis #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Systemic lupus ... SJIA], systemic lupus ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients)
Important notes:
 • No
calculators - HAS-BLED ... fibrillation) and ... validated for VTE treatment ... studies suggest net clinical ... Anticoagulation #Factors #Hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
myopathy • Anti MAG ... to cold IgG • Lupus ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Monoclonal #Differential