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diagnosis hematology management oncology differential leukemia chronic cll syndrome abscess acute algorithm cbc classification hemeonc hemophagocytic hiv hlh hodgkins lung
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Vmphocytosis on routine CBC ... transformation) Treatment ... Indications for Treatment ... AIHA, PRCA) • Treatment ... Leukemia #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... surface molecules: CD5 ... • Neutropenia, anemia ... microglobulin Treatment ... workup #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... eosinophilia, basophilia ... Neutrophils • Immature/Myeloblasts ... - infiltrates (anemia ... #Leukemia #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Artifact (redo CBC ... effect following treatment ... Iron deficiency anemia ... #Hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... on the left Myeloblast ... Degree of bandemia ... neutrophil #WBC #CBC ... #hematology #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... Drugs, Unknown cause ... Treatment: • ... #summary #rheumatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
14%), in which case ... • Leukocyte-lymphocyte ... enzymes ↑ • Mild anemia ... Photophobia • Lymphocytic ... antibody test) Treatment
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
• Most common cause ... Lung Abscess Pathophysiology ... Diagnosis: • CBC ... Leukocytosis, anemia ... #differential #causes
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
HL (MCHL) - Lymphocyte ... HL (LRHL) - Lymphocyte ... LDHL) - Nodular lymphocyte ... Hodgkin Lymphoma Treatment ... classification #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
glands: • Focal lymphocytic ... Hypocomplementemia • Can cause ... /aggregate) of CD4 ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
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