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diagnosis hematology management oncology leukemia algorithm chronic cll lymphocytic signs wbc aflp anemia anorexianervosa aplastic arteritis bands cancer cardiology causes
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... after initial Rx), basophilia ... hematology #WBC #Leukemoid
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
cells within the myeloblast ... eosinophils, & basophils ... Leukemoid reaction ... part automated differential ... NEUTROPHILS #WCC #BASOPHILS
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... eosinophilia, basophilia ... Neutrophils • Immature/Myeloblasts ... - infiltrates (anemia ... Transformation: • Complication
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Script Signs and symptoms ... • Symptomatic anemia ... neutropenic fever) Complications ... to MDS or acute leukemia
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Neutrophil (Normal) Differential ... Tissue damage • Leukemia ... #differential # ... CBC #hematology #pathophysiology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic Leukemia ... • Most common leukemia ... Splenomegaly 5) Symptoms ... Complications: ... Constitutional symptoms
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... with no early symptoms ... • Neutropenia, anemia ... kinase (BTK) Complications ... • GI complications
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... postpartum): • Initial symptoms ... infiltration) Differential ... Monitor and Treat Complications ... diagnosis #management #pathophysiology
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
Pulse Pressure - Differential ... Diagnosis and Pathophysiology ... iron deficiency anemia ... • Sepsis Complications ... #Diagnosis #Pathophysiology
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
severe clinical complications ... overload) Other Symptoms ... Syndrome #Nutrition #Differential ... #Diagnosis #Pathophysiology
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