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White Blood Cell Maturation Chart

#Pathology #WBC #Maturation #Lineage #Chart #Leukocyte #Myeloid #Myeloblast #Lymphocyte
#Pathology #WBC ... Leukocyte #Myeloid #Myeloblast
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases

Acanthocyte (spur cell),  
Basophilic stippling, 
Bite cell,
Red Blood Cell (RBC ... spur cell), Basophilic ... cell, Other RBC ... Howell-Jolly bodies #RBC
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
cells within the myeloblast ... eosinophils, & basophils ... Mature WBC: 80- ... LEUCOCYTOSIS WBC ... NEUTROPHILS #WCC #BASOPHILS
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Common RBC Inclusions ... Hemoglobin H disease • Basophilic ... Sickle cell, MDS #RBC
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
platelets, persistent WBC ... after initial Rx), basophilia ... Algorithm #hematology #WBC
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased Heme Synthesis or
- Fe/TlBC, MCV/RBC ... TIBC Normal - MCV/RBC ... <13, +/- basophilic ... inclusions in RBC
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
thalassemia, S Lepore • Basophilic ... hypertension • Unusual RBC ... acanthocytes - Consider RBC
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... #CBC #hematology
Nucleated red blood cells, aka normoblasts or erythroblasts, were released prematurely from the bone marrow in
proerythroblast – basophilic ... Smear #Nucleated #RBCs
Morphologic Findings in Red Blood Cells
Basophilic stippling - Small blue dots in red cells, due to
Red Blood Cells Basophilic ... and grayer than basophilic ... RedBloodCells #RBCs