Nucleated red blood cells, aka normoblasts or erythroblasts, were released prematurely from the bone marrow in these newborns because of hypoxia. The arrow points to a polychromatophilic normoblast. The other nucleated cells are orthochromic normoblasts. In the fetus/newborn the causes of hypoxia are many and varied, including Rh incompatibility and ABO incompatibility. Normal maturation of red cell precursors to mature erythrocytes goes through several stages; proerythroblast – basophilic normoblast – polychromatophilic normoblast – orthochromic normoblast – reticulocyte – mature. #Clinical #Path #Peds #BloodSmear #Blood #Smear #Nucleated #RBCs #NucleatedRBCs #Normoblast
