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differential rheumatology management workup hepatology syndrome treatment ana antibody antinuclear causes disease patterns algorithm anemia arthritis cirrhosis cppd cytoplasmic gout
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
Red Blood Cell (RBC ... cell, Other RBC ... Microscopy #Pathology #Hematology ... #Diagnosis #Dyspmorphic ... #BloodSmear
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Differential Diagnosis ... especially in the setting ... #CBC #hematology ... #pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology ... Proximal limb muscle wasting ... Diagnosis: • ... Differential Diagnosis ... #workup #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... smear, HIV/HCV testing ... or if a primary hematologic ... #Differential #Diagnosis ... Causes #Workup #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... hypertension • Unusual RBC ... #Differential #Diagnosis ... Algorithm #workup #hematology ... #testing
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody Testing ... , PBC/SjS OS ... Antinuclear #Antibody #Testing ... #differential #diagnosis ... #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... blasts and high WBC ... • Lab values: WBC ... Syndrome #TLS #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... if high risk if WBC ... opacities • Diagnosis ... QD until normal WBC ... #management #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Positive Coombs testing ... Blood smear - RBC ... post infectious setting ... hemolytic #anemia #hematology ... #diagnosis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
pericarditis • Hepatic: PBC ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... #symptoms #testing
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