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White Blood Cell Maturation Chart

#Pathology #WBC #Maturation #Lineage #Chart #Leukocyte #Myeloid #Myeloblast #Lymphocyte
#Pathology #WBC ... Leukocyte #Myeloid #Myeloblast
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
large, immature myeloblasts ... Clinical #Path #BloodSmear
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
cells within the myeloblast ... white blood cell (WBC ... Mature WBC: 80- ... LEUCOCYTOSIS WBC ... ) and immature WBCs
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases

Acanthocyte (spur cell),  
Basophilic stippling, 
Bite cell,
Red Blood Cell (RBC ... cell, Other RBC ... Howell-Jolly bodies #RBC ... #Dyspmorphic #BloodSmear
A normal peripheral blood smear indicates the appropriate appearance of red blood cells, with a zone
the size of the RBC ... PeripheralBloodSmear #BloodSmear
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... diagnosis #neutrophil #WBC
Peritonitis - Spontaneous vs Secondary vs Peritoneal Dialysis Associated Peritonitis
Spontaneous Bacterial Peritonitis
 • Cirrhosis (high SAAG)
PMN > 250 • Treatment ... cloudy effluent) 2) WBC ... > 100 WBC, >50% ... Positive Culture • Treatment
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... • Lab values: WBC ... organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... if high risk if WBC ... Renal Failure Treatment ... QD until normal WBC
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
↑ LDH • Anti-RBC ... diagnosis #management #treatment