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differential management rheumatology oncology erythematosus leukemia lupus systemic acute cauda caudaequina cerebritis chronic dermatology disorders equina guillain guillainbarre hiv lymphocytic
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
procedures - Infection ... decreased PLT count: CBC ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... #Causes #Workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... Neutrophils • Immature/Myeloblasts ... #Leukemia #Hematology ... #Oncology #Diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... APS), Secondary prevention ... #CNS #neurology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... weeks without infection ... Lymphocytosis on CBC ... #workup #oncology ... #hematology
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... response preceding infection ... Diagnosis: • ... #Syndrome #diagnosis ... #neurology
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
(CES) is usually ... cord • Guillain-Barre ... Laboratory studies: • CBC ... axial T1 and T2 Treatment ... #causes #neurology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... fibromyalgia) • Infections ... Malignancy (e.g. hematologic ... and CNS • Headache ... titers > 1:80 • CBC
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
+ T-cell count can ... DDX: • Epstein-Barr ... • New onset SLE ... antibody test) Treatment ... ART to slow HIV disease
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... /aggregate) of CD4 ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... mononeuritis multiplex WORKUP ... coagulopathy) • CBC ... confirm DAH, r/o infection ... #management #treatment
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