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diagnosis oncology differential chronic cll leukemia lymphocytic workup agglutinin algorithm anemia atlas bloodcell cold erythematosus hemeonc hemolytic hemophagocytic hlh hodgkins
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... , Auer rod • Lymphoid ... bcr-able (+) ↑ WBC ... @AmyChung #Blood ... #Disorders #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... Target Cell RBC ... differential #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... can indicate disease ... lymphoproliferative disorders ... microglobulin Treatment ... workup #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
leukemia in adults • Disorder ... Vmphocytosis on routine CBC ... lymphoma (Richter ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
of peripheral blood ... Left Shift: • Cell ... on the left Myeloblast ... • Autoimmune diseases ... #CBC #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... number of sites of disease ... Treatment • Early ... #hematology #oncology ... #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
or lymphoid malignancy ... - Lymphoid Malignancy ... malignancies - B-cell ... sensitize red blood ... #hematology #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Phagocytosis of blood ... lymphoma, B-cell ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... lymphoma • Evans ... titers > 1:80 • CBC ... : • Chronic B-cell ... Erythematosus #Diagnosis #Rheumatology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Biopsy: Solitary disorder ... • CBC + diff • ... Bone marrow Treatment ... • Non-Hodgkin Lymphoma ... Diagnosis #Workup #Hematology
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