11 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... Malaise, bleeding, infections ... pain, bleeding, infections ... Neutrophils • Immature/Myeloblasts ... bruising, bleeding, infection
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
large, immature myeloblasts ... acute myelogenous leukemia ... (AML) that is most ... prevalent in young adults ... Path #BloodSmear #Blood
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
cells within the myeloblast ... In adults, leukocytosis ... in peripheral blood ... solid tumors, and bacterial ... infections.
Blood Culture Collection Algorithm - Adult Patients with Suspected Systemic Infection 

Pawlowicz et al evidenced based
Algorithm - Adult ... Pawlowicz et al ... Implementation-of-an-evidence-based-algorithm-reduces-blood-culture-overuse-in-an-adult-emergency-department.php ... with suspected bacterial ... suspected source of bacterial
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
in adults in the ... Affects mainly older adults ... weeks without infection ... Lymphocytosis: Absolute blood ... Transform to DLBCL, PML
IDSA Recommendations for Preventing and Treating Bacterial Enteric Infections in HIV-AIDS
Preventing Bacterial Enteric Illness:
 • Antimicrobial
IDSA Recommendations ... Enteric Infections ... if MIC<0.12 ug/ml ... #IDSA #Prevention ... #HIVAIDS #pharmacology
Septic Arthritis: Pathogenesis and clinical findings
Notes:
- Septic Arthritis is typically monoarticular & the knee is involved
cases - decr blood ... Microbiology: - Bacterial ... infection is most ... pathogen across all ... gonorrhoeae in young adults
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... Ferritin >1000 ng/ml ... sIL-2R >2400 Ul/ml ... CMV, HHV8,...), Bacteria ... diseases: SLE+++, Adult-onset
Antimicrobial Regimens for Acute Bacterial Rhinosinusitis in Adults
Initial empirical therapy: 
 • Amoxicillin-clavulanate (500 mg/125 mg
Regimens for Acute Bacterial ... Rhinosinusitis in Adults ... PO qd) Severe infection ... Antimicrobial #empiric #idsa ... #management #pharmacology
IDSA Recommendations for Preventing and Treating Varicella Zoster Virus (VZV) Infections in HIV-AIDS
Pre-Exposure Prevention of VZV
IDSA Recommendations ... Indications: • Adult ... , 2 doses (0.5 mL ... #Zoster #VZV #IDSA ... #HIVAIDS #pharmacology