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differential hematology oncology algorithm management classification hiv hodgkins syndrome acute aids apl auerrods blood bloodsmear chronic clinical cll cns comparison
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• Cytopenia -> BM ... -> AML: Blast crises ... • Immature/Myeloblasts ... Age: 50-60 • Auer ... #Oncology #Diagnosis
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
She was diagnosed ... promyelocytic leukemia ... a bone marrow (BM ... hospitalization and treatment ... acute myeloid leukemia
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 Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Lymphadenopathy ... - Differential Diagnosis ... Infectious • EBV ... #Algorithm #Causes
Differential Diagnosis for Generalized Lymphadenopathy Viral • HIV • EBV • CMV • HBV • Dengue • Rubella
Differential Diagnosis ... Viral • HIV • EBV ... Malignancy • Lymphoma ... • Leukemia • ... #Causes #Algorithm
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome - Causes ... and Treatment ... hyperleukocytosis (AML ... - MH/CCF/CWRU EM ... #Differential #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Exam/Signs: • Lymphadenopathy ... phenomenon CLL Diagnosis ... microglobulin Treatment ... Transform to DLBCL, PML ... #diagnosis #workup
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... (NHL) ~60% - lymphadenopathy ... Responsive to Treatment ... Treated Like Acute Leukemias ... relapse - Amy
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g., HIV), EBV ... involved) • No leukemic ... disease: B symptoms, lymphadenopathy ... Differential Diagnosis ... comparison #oncology #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... • History of EBV ... Presentation: • Lymphadenopathy ... Treatment • Early ... #diagnosis #classification
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hodgkin, T-cell lymphoma ... , B-cell lymphoma ... Drugs, Unknown cause ... Treatment: • ... #management #treatment
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