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oncology algorithm bandemia basophilia basophils cbc dermatologic eosinophilia gpa granulomatosis lymphocytic mds myelodysplasia myelodysplastic neutrophil polyangiitis rash secondary syndromes thrombocytopenia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... -> AML: Blast crises ... Neutrophils • Immature/Myeloblasts ... #Hematology #Oncology ... #Diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Megakaryopoiesis • Aplastic ... Leukemia, Tumour ... ITP • SLE • CLL ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential ... myeloid leukemia ... (CML) - Dr. ... #Diagnosis #Causes ... #hematology #secondary
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Orange or Hep C Clinical ... aplasia • ITP ... #Leukemia #diagnosis ... workup #oncology #hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
- Differential ... Primary: - CML ... Hypereosinophilic Syndrome - Chronic ... #Diagnosis #Causes ... #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Diagnosis Framework ... Disorders: • Chronic ... #Diagnosis #causes ... #hematology #basophils
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Nasopharyngeal carcinoma ... Polyangiitis #GPA #dermatology ... #rheumatology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... on the left Myeloblast ... Tissue damage • Leukemia ... #WBC #CBC #hematology ... #pathophysiology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Anemia • Aplastic ... Marrow Failure • Chronic ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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