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management oncology differential algorithm aplastic bandemia cbc coagulation common cvid dermatologic dic gpa hemolytic hypogammaglobulinemia immunodeficiency immunology intravascular maha mds
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
• Bleomycin Hematologic ... • Sickle Cell Anemia ... • Klebsiella granulomatis ... ulcerative #skinrash #dermatology ... #Algorithm #causes
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Polyarteritis nodosa • Microscopic ... Nasopharyngeal carcinoma ... Polyangiitis #GPA #dermatology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... and laboratory diagnosis ... conditions such as disseminated ... #Hematology #Pathology ... #Smear #Microscopy
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... Neutrophils • Immature/Myeloblasts ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... on the left Myeloblast ... Tissue damage • Leukemia ... likelihood of negative clinical ... neutrophil #WBC #CBC #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... virus (EBV) • Leukemia ... #oncology #hematology ... #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... promyelocytic leukemia ... organ damage Clinical ... #Coagulation #diagnosis ... #management #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
late adulthood • Diagnosis ... to 8 years Clinical ... autoimmune hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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