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hematology oncology purpura algorithm bleeding classification hemostasis hodgkins lymphoma management mds myelodysplasia myelodysplastic nonpalpable palpable pediatrics peds rheumatology secondary syndromes
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Differential Diagnosis ... Reactive: • Anemia ... Chronic Myeloid Leukemia ... Diagnosis #causes ... #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential ... Chronic inflammatory disorders ... Chronic myeloid leukemia ... Diagnosis #Causes
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential ... Chronic Myelogenous Leukemia ... • Rheumatic disorders ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... : • DIC, TTP/HUS ... #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... or Easy Bruising ... infiltration (e.g. leukaemia ... pediatrics #diagnosis ... #differential #
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... basophilia, and thrombocytosis ... Neutrophils • Immature/Myeloblasts ... PLT: Petechiae, bruising ... #Diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... Diagnosis Framework ... gingivitis or gingival leukemic ... discern these causes ... #Diagnosis #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... Easy or unusual bruising ... • Hairy Cell Leukemia ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
persons • It has ... • Autoimmune disorders ... - Low Hb and platelets ... lymph node biopsy (diagnostic ... Immunohistochemical studies (to differentiate
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