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differential algorithm prolonged pt anemia aplastic arterial bleeding bruising dic disseminated embolism gastroenterology hemochromatosis hemostasis intravascular microangiopathy oncology pathophysiology thrombosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... deficiency) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... #diagnosis #causes ... #hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
and Management ... TMA: Unexplained thrombocytopenia ... hemoglobin/hemosiderin, Hepatic ... normal • DAT ... #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... e.g. heparin ... #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... thrombin inhibitors, heparin ... #Causes #diagnosis ... #differential #hematology ... #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/ABNORMAL PTT ... Acquired: • Heparin ... PT/ABNORMAL PTT ... discern these causes ... #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... Hyperhomocysteinemia - Heparin-induced ... thrombocytopenia ... intravascular coagulation ... pathophysiology #hematology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. Step 1: In the patient with
regarding the diagnosis ... elevated iron indices ... including liver and hematologic ... hemochromatosis; HIC, hepatic ... #management #hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
infections/fevers • Thrombocytopenia ... and petechiae Causes ... virus (EBV) • Leukemia ... Anemia #oncology #hematology ... #diagnosis #management
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